生化标志物检测在急性心肌梗死（AMI）诊断中的应用
生化标志物检测在急性心肌梗死（AMI）诊断中的应用(论文8600字)
摘要
目的: 讨心肌生化标志物肌酸激酶同工酶(CK-MB) 、肌钙蛋白T(cTnT)在急性心肌梗死(AMI)早期诊断中的临床应用，为急性心肌梗死患者的诊治提供可靠的理论依据。方法: 收集湖南中医药研究院附属医院检验科AMI患者和健康体检者共计200例患者、100例AMI患者以及100例健康体检者的血清，采用免疫抑制法检测血清中的肌酸激酶MB同工酶(CK-MB)和肌钙蛋白T(cTnT)。结果: 1、AMI患者组血清CK-MB、T(cTnT) 水平显著高于对照组（P＜0.01），且AMI组升高幅度更为明显；2、AMI组中，CK-MB、T(cTnT) 水平随病情发展而显著升高（P＜0.01）；3、CK-MB、T(cTnT) 在AMI组的曲线下面积（area under curve, AUC）分别为0.56、0.75。结论: 本研究结果显示，CK-MB、T(cTnT) 对AMI早期有一定的诊断价值，可预示AMI疾病的发生、估计梗死范围、及早对患者做出治疗,有效地降低病死率。
关键词：急性心肌梗死；心肌生化标志物；肌酸激酶同工酶；肌钙蛋白T
Abstrac
Objective: To investigate the clinical application of creatine kinase isoenzyme (CK-MB) and troponin T (cTnT) in the early diagnosis of acute myocardial infarction (AMI), and to provide reliable theoretical basis for the diagnosis and treatment of acute myocardial infarction. [来源：http://www.doc163.com]
Methods: AMI patients and healthy subjects were enrolled in a total of 200 patients, 40 patients with AMI and 50 healthy subjects. The serum creatine kinase MB isoenzyme was detected by immunosuppressive method. CK-MB) and troponin T (cTnT) .
Results: The level of CK-MB and T (cTnT) in the AMI group was significantly higher than that in the control group (P <0.01), and the elevation of the AMI group was more obvious. (2) The level of CK-MB and T (cTnT) (P <0.01) .3. The area under the curve (AUC) of CK-MB and T (cTnT) in the AMI group (stage Ⅳ) were 0.56, 0.75.
Conclusion: The results show that CK-MB, T (cTnT) on the early diagnosis of AMI value, can predict the occurrence of AMI disease, estimated infarct size, early treatment of patients, effectively reduce the mortality.
Key words: Acute myocardial infarction; myocardial biochemical markers; creatine kinase isoenzyme; troponin T.
目 录
中文摘要 Ⅰ
英文摘要 Ⅱ
前言 1
1 对象与方法 2
1.1 对象 2
1.2 检验方法 2
1.3 统计分析 3
2 结果 4
2.1 一般结果 4
2.2 AMI各期CK-MB、T(cTnT)水平的比较 4
2.3 CK-MB与T(cTnT)的Logistic回归分析结果 6
3 讨论 8
4 结论 10
参考文献 11
致谢 13
综述 14 [资料来源：https://www.doc163.com]